Forschung
Research
Univ.-Prof. Dr. rer. nat.
Barbara Grünwald
Head of Experimental Urology. Research Group Leader: Translational Systems Biology
Heterogeneity in Solid Tumors
Harnessing tumoural heterogeneity for a better understanding of tumor biology and improvements in clinical practice
Welcome to the Urology Research Lab! We are a collaborative, diverse, and interdisciplinary team of scientists seeking to understand the biology of solid tumor tissues across urological, pancreatic, and lung cancer.
The notorious heterogeneity of tumors at the cellular and spatial level is not random noise but a fundamental basis on which solid tumor tissues operate. We therefore envision that a deep understanding of the foundations and consequences of tumor heterogeneity can and should inform clinical practice. Of particular interest to us are the different non-malignant components of solid tumors and how they self-organize to control tumor properties such as growth, invasion, and drug resistance. In close collaboration with our partners from the clinic, we strive to derive both mechanistic insights and develop clinically feasible tools to effectively navigate tumor heterogeneity in clinical decision making.
Prof. (apl) Dr.
Tibor Szarvas
Head of Uro-Oncology Group
Join our team!
We are always looking for ambitious young researchers to join our team. Please check out the In The Lab section and reach out if you are interested and/or have questions about working with us!
News & Announcements
- Our hourglass tool was covered in a commentary by Derya Bakırdöğen. Couldn’t have explained it better ourselves! https://pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.6268
- New paper alert! Check out Fabian’s CellViT, a new method for automated instance segmentation of cell nuclei in digitized tissue samples using deep learning. Great collaboration with the Kleesiek lab! https://pubmed.ncbi.nlm.nih.gov/38507894/
- New paper alert! The complex dynamics of breast cancer tumorigenesis and metastasis downstream of DPP-9, laid out in detail for you by Lisa Heß from the Reinheckel Lab in Freiburg: https://pubmed.ncbi.nlm.nih.gov/38531482
- Happy 1st Labiversary everyone!!!
- Our work exploring drivers of intratumoural subtype heterogeneity in pancreatic cancer carried out in collaboration with Shiv K Singh in Göttingen is now available on bioRxiv